1. Studying the Effect of Water Ingress on API Adhesion in Suspension Metered Dose Inhalers using AFM
J. James [1], M. Davies [1], R. Toon [2], P. Jinks [2] and C. J.Roberts [1]
[1] The University of Nottingham, [2] 3M Drug Delivery Systems
2. An Investigation into the Physical Interactions of a Model Clathrate in a Suspension Metered Dose Inhaler Formulation
A. Bouhroum [1], N. Champness [2], J. James [1], C. Roberts [1], R. Toon [3] and P. Williams [1]
[1] School of Pharmacy, University of Nottingham, [2] School of Chemistry, University of Nottingham, [3] 3M Drug Delivery Systems
3. Investigation of the Ageing of Ball Milled Sugars and Sugar Alloys
T. Gould [1], R. Toon [2], S. Fletcher [1]
[1] Loughborough University, [2] 3M Drug Delivery Systems
4. Comparison of two methods to prevent evaporation of aqueous droplets in the Andersen Cascade Impactor
Thomas Hubrath, Jürgen Kumb
Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany
5. Investigating Blend Relaxation Effects on Lactose Blends Produced Using a High Shear Process
Andrew Edwards*, John Murphy, Barry Aldous, Jordan Cheyne, Rachel Brody, Ljiljana Harding
Pfizer Global Research and Development, *School of Life Sciences, University of Hertfordshire
6. Is It Possible To Predict The Milling Behaviour of Indomethacin Polymorphs Using Standard Computational Techniques?
Fiona Robinson
Institute of Pharmaceutical Innovation, University of Bradford
7. A Visual Indicator for Inhalation from a Valved Holding Chamber (VHC) is an Important Attribute when Delivering Inhaled Medication to Infants
Jolyon Mitchell, Valentina Avvakoumova, Heather Mackay, Rubina Ali and Mark Nagel
Trudell Medical International
8. In Vitro Comparison of a Breath-Actuated Nebulizer (BAN) for the Delivery of Salbutamol Solution When Operated with Either Compressed Heliox or Air
Jolyon Mitchell†, Valentina Avvakoumova†, Mark Nagel† Cathy Doyle† and Dominic Coppolo‡
†Trudell Medical International, London, Canada, ‡Monaghan Medical Corporation, NY, USA
9. The Abbreviated Impactor Measurement (AIM) Concept: Influence of Particle Bounce and Re-Entrainment – Application to the Copley Fast Screening Andersen Impactor (C-FSA
Jolyon Mitchell, Heather Mackay, Valentina Avvakoumova, Rubina Ali and Mark Nagel
Trudell Medical International, Canada
10. Substantial In Vitro Equivalence Exists for Anti-Static and Non-Static Versions of the Same Valved Holding Chamber (VHC) Family Provided Pre-Washing of the Non-Static Version is Undertaken to Mitigate Electrostatic Charge
Jolyon Mitchell*, Valentina Avvakoumova, Heather Mackay, Rubina Ali and Mark Nagel
Trudell Medical International, Canada
11. Cascade Impactor Mensuration – An Assessment of the Accuracy and Precision of Optical Measurement Systems
Frank Chambers*, Jolyon Mitchell¶ and Christopher Shelton†
European Pharmaceutical Aerosol Group (EPAG) *AstraZeneca plc, UK, ¶Trudell Medical International, Canada, †PPD Inc, USA
12. Air Flow Meters Used at Testing of Inhalation Products – An Inter-Laboratory Comparison
Lars Asking†, Jolyon Mitchell* and Steven Nichols#
European Pharmaceutical Aerosol Group (EPAG)
†Novo Nordisk, Denmark, *Trudell Medical International, Canada, #OINDP Consultant, UK
13. Formulation of clean bromobutyl elastomer composition using a xanthogen polysulphide accelerator for sealing medical devices
D.S.Ohbi [1], R Warby [1], T. Shah [2], and E.Siores [2]
[1] Bespak Division, UK. [2] University of Bolton
16. Investigation of Fundamental Powder Flow Properties of Fine Lactose Particles Following Mechanical Surface Modification
Q Zhou [1], B Armstrong [2], D A V Morton [1] and P J Stewart [1]
[1] Monash University, Australia [2] Freeman Technology
17. Investigation of Powder Changes on Delivery Characteristics from a Penn Century Dry Powder Insuflator™
M P McIntosh, S Agarwal and D A V Morton
Monash University, Australia
18. In vitro evaluation of powders for inhalation: the effect of drug concentration on particle detachment
T.H. Hoang Thi1, E. Robins [2], M.P. Flament [1]
[1] College of Pharmacy, Department of Pharmaceutical Technology, France, [2] VALOIS S.A., France
19. Flow Rate Ramp Profile Effects on the Emitted Dose from Dry Powder Inhalers
Kyle L. Beron, Catherine E. Grabek, Jeff A. Jung and Christopher M. Shelton
PPD, Inc, USA
20. Effect of Mucolytic Therapy on Drug Delivery through Cystic Fibrosis Sputum
J. Shur [1], R.Price [1], J. Smith [2] and J. Shute [2]
[1] University of Bath, UK, [2] University of Portsmouth
21. Probing Interparticulate Forces Using Powder Rheology
J. Shur [1], P. Rogueda [2], J. S. Kaerger [2] and R. Price [1]
[1] University of Bath, [2] Novartis Pharmaceuticals UK Ltd
22. De Novo Engineering of Crystalline Low Dose Combination Inhalation Particles of a
Long-acting β2-agonist and Corticosteroid
Chonladda Pitchayajittipong, Jagdeep Shur, and Robert Price
University of Bath
23. The influence of crystallization processes on the nano-mechanical properties of fluticasone propionate
H. Kubavat, J. Shur and R. Price
University of Bath
24. A Calorimetric Method for Optimising Milling of Pharmaceuticals
Mansa Dennison [1], Simon Gaisford [1] Matthew Jones [1] & Mark Saunders [2]
[1] University of London, [2] Synectix Pharmaceutical Solutions Ltd
26. Comparison of Atomic Force Microscopy and Inverse Gas Chromatography for the Prediction of Dry Powder Inhalation Performance
M D Jones and G Buckton
University of London
27. The Relationship Between Drug Concentration, Mixing Time, Blending Order and Ternary Dry Powder Inhalation Performance
M D Jones, JGF Santo, B Yakub, M Dennison, H Master and G Buckton
University of London
28. Characterisation of Particles Emitted from Beclomethasone Dipropionate Solution Metered Dose Inhalers
Mark Saunders1, Francesca Buttini2, Chris Grainger3, Ben Forbes3, Paul G. Royall3, Piers Lincoln4, Stuart A. Jones3
[1] Synectix Pharmaceutical Solutions Ltd, [2] University of Parma, Italy, [3] King’s College London,
[4] University of Bradford
29. Utility of Gamma Scintigraphy in Assessing Mucociliary Clearance in COPD
M Limb [1], R Bacon [1], P Scholes [1], M Longphre [2]
[1] Pharmaceutical profiles Ltd, [2] Aerovance Inc, USA
30. Precipitation of insulin microparticles for pulmonary delivery
C Klingler, H Steckel, B W Müller
Christian Albrecht University, Germany
31. Decreased treatment times with aerosolized iloprost following increase in power levels for the I-neb Adaptive Aerosol Delivery (AAD) System
Robert Van Dyke [1] and Kurt Nikander [2]
[1] Actelion Pharmaceuticals US, Inc., USA; [2] Respironics, Inc.,USA
32. The Aerodynamic Deposition of Drugs from Combination DPI Formulations: The Influence of Particle Size and Drug-Drug and Interactions
M Taki [1], C Marriott [1], XM Zeng [2] & GP Martin [1]
[1] King's College London, UK; [2] TEVA Pharmaceuticals, Global Respiratory R&D, USA
33. Comparison of EPAG and Respironics Next Generation Impactor Test Protocols using Cooled and Ambient Conditions
L E Hardaker & R H M Hatley
Respironics Respiratory Drug Delivery (UK) Ltd
34. Model for the Prediction of Internal Flow Conditions
in Pressurised Metered Dose Inhalers (pMDIs)
Abdul Q. Shaik & Henk K. Versteeg
Loughborough University
35. A new high performance dual-layer coating for inhalation hardware
P A Jinks
3M Drug Delivery Systems, UK
36. The Benefits of Fast Fill Fast Empty Valves to Patient Compliance
Daniel Clarke
3M Drug Delivery Systems, UK
37. Room Temperature Stable Formoterol Metered Dose Inhaler Systems with Consistent Delivery Characteristics
P Bainbridge & P A Jinks
3M Drug Delivery Systems, UK
38. The Changes in Dispersion of Salmeterol Xinafoate-Lactose Mixtures During Storage at Different Relative Humidities
S Das [1], I Larson [1], P Young [2] & P Stewart [1]
[1] Monash University, Australia, [2] University of Sydney, Australia
39. In-situ fine particle excipient as dispersion modifier for a dry powder inhalation product
R Westmeier & H Steckel
Christian Albrecht University Kiel, Germany
40. Soft-pelletization of micronized substances:
Development of a novel, continuous production process
Hartmann, T. & Steckel, H.
University of Kiel, Germany
41. White Light Spectroscopy – a new approach in Aerosol Particle Sizing
M Kuhli [1], L Moelter [2], F Munzinger [2] and H Steckel [1]
[1] Christian Albrecht University, Germany, [2] Palas® GmbH, Germany
42. Statistical analysis of Andersen Cascade Impaction mensuration data
Andy Cooper and Chris Blatchford
3M Drug Delivery Systems Ltd, UK
43. Investigating Analyst Error in Andersen Cascade Impaction
Jay Adamson
Covance Laboratories Ltd, UK
44. Comparison of aerosol delivery efficiency nebulising Colistin by electronic and jet nebulisers
Ellen Bitterle, Oliver Denk, Anke Luithlen, Karin Reul, Karina Hoyer, Monique Uhlig, Markus Tservistas, Manfred Keller
PARI Pharma GmbH, Germany
45. Understanding The Relationship Between Formulation Viscosity And Nebuliser Performance
M Copley [1], M Hammond [2] & P Kippax [3]
[1] Copley Scientific, UK. [2] Melbourn Scientific, UK.
46. Automated Foreign Particulate Matter Testing for Pharmaceutical Inhalation Products
D Huck, N Davidson & U Willen
Malvern Instruments Ltd, UK
47. Monitoring of droplet size changes in a suspension pMDI by Laser diffraction on a SympatecTM instrument
Andy Cooper and Thomas Bell
3M Drug Delivery Systems, UK
48. Characterisation and Functionality of Anhydrous Inhalation Lactose
C Pitchayajittipong [1]*, J Shur [1], J S Kaerger [2], S Edge [3] & R Price [1]
[1] University of Bath, UK, [2] Aeropharm GmbH, Germany, [3] Novartis Pharma AG, Switzerland
49. Using Computer Modelling to Investigate the Effect of Inhaler Design, and Patient Variation in the Deposition of Particles in the Upper Airway of Paediatric Patients
Ruth Underwood [1], Françoise Dufour [1], Gavin Davies [1], Andrew Pocock [2], Suresh Gupta [2]
[1] Arup, UK, [2] Team Consulting Ltd, UK
50. Quality By Design For pMDIs: Designing The Necessary Tools.
10 Years Of Pressure Techniques
Philippe G Rogueda
Novartis Horsham Research Centre, UK
51. A Review of CFD Applications to Pulmonary Drug Delivery: Pros, Cons and Gaps
F. Dufour¹, S. Nichols², S. Downie¹ & G. Davies¹.
¹Arup, UK, ²OINDP Consultant, UK
52. Physicochemical characteristics of a liposomal ciclosporin A formulation pre and post nebulisation in a customized eFlow® electronic nebulizer
Roman Egle, Ellen Bitterle, Friedrich Gruber, Manfred Keller
PARI Pharma GmbH, Germany
53. The time-dependent effect of airflow profile on DPI performance
David Blakey, David Harris and Jonathan Wilkins
Cambridge Consultants, UK
54. Spraytec Real Time Droplet Sizing System (Spraytec RTSizer) - A Robust Method for Rapid Screening of Nebulized Formulations
Lei Mao, Kristie Hamby, David Wilcox
Catalent Pharma Solutions, USA
55. A Platform Technology for Developing Dry Powder Inhalation Formulations of New Chemical Entities from Feasibility Evaluation to Clinical Batch Manufacturing – A Case Study
Lei Mao, Christy Gilbert, Jenifer Matzer, James Fulcher, Craig Davies-Cutting
Catalent Pharma Solutions, USA
56. Unravelling the behaviour of HFA propellants: Building a case for a halogen bond
Philippe G. Rogueda
Novartis Horsham Research Centre, UK
57. Influence of Fine Excipient Lactose Grades on Powder Fluidization and Performance of
Dry Powder Inhaler Formulations
J Shur, C Pitchayajittipong, J S Kaerger [2], P. Rogueda [2] & R Price [1]
[1] University of Bath, [2] Novartis Pharmaceuticals UK Ltd
58. Advancements in ease of dosing for nebulised drug products:
Development of a closed, ampoule-based electronic nebulizer system
T. Gallem, M. Tservistas , M. Uhlig, A. Seidler, R. Waldner, S. Seemann, M. Keller, M. Knoch
PARI Pharma GmbH, Germany
59. LC-MS-MS Methodologies for the Quantification of Trace Levels of Extractable/Leachable Components in Dry Powdered Inhaled Formulations
M. D. Hodgson
Pfizer Ltd, UK
60. Recommendation to use a climate box for optimisation of cascade impaction measurements ensuring exact control of humidity and impactor temperature
Ellen Bitterle, Anke Luithlen, Karin Reul, Albert Bucholski and Manfred Keller
PARI Pharma GmbH, Germany
61. Investigation of relaxation kinetics of hydrophobic drug substances upon micronisation
Frank Thielmann [1], Daniel Burnett [2] and Theodore Sokoloski [3]
[1]Novartis Pharma, Switzerland, [2]Surface Measurement Systems, UK, [3] Ohio State University, USA
62. Solubility Determination in HFAs determined by coaxial NMR
Mark Saunders [1], Philippe Rogueda [2], Richard Telford [3], Ian Scowen [3],
[1] Synectix Pharmaceutical Solutions Ltd, UK, [2] Novartis Horsham Research Centre, UK
[3] University of Bradford
63. Device Output is not a Predictor of Lung Dose
P Kroneberg [1], W Zimlich [2], B Muellinger [1], A Wenker [1] and G Scheuch [1].
[1] Activaero GmbH, Germany, [2] Activaero America Inc, USA
64. In vitro System to assess the size-dependent dissolution profile of inhalable aerosols
R Cartier, M Egen & M Krüger
Boehringer Ingelheim Pharma GmbH & Co. KG, Germany
Poster PDFs DDL19
